Toward Multi-Input Control: A Dual-Feedback Loop Model of the Mammalian Circadian Clock
نویسندگان
چکیده
منابع مشابه
Toward a detailed computational model for the mammalian circadian clock.
We present a computational model for the mammalian circadian clock based on the intertwined positive and negative regulatory loops involving the Per, Cry, Bmal1, Clock, and Rev-Erb alpha genes. In agreement with experimental observations, the model can give rise to sustained circadian oscillations in continuous darkness, characterized by an antiphase relationship between Per/Cry/Rev-Erbalpha an...
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ژورنال
عنوان ژورنال: IFAC-PapersOnLine
سال: 2018
ISSN: 2405-8963
DOI: 10.1016/j.ifacol.2018.09.022